2. Holly Marie Combs
Holly, who had her first major television roles in the soap operas Guiding Light and As the World Turnsmore more than 20 years ago, landed her first long-lived role when she was accepted to the ensemble series Picket Fences. Her next major role was as Piper Halliwell in Charmed, the supernatural series that ended in 2006. While Holly is the scene stealer wherever she appears, she hasn’t had a major role since then – something she truly deserves, with her talent and looks.